Author: Overcoming Adversity | Buteau’s Odyssey

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In my previous post, I shared my journey discovering that low-dose sublingual (LDSL) ketamine produces remarkable results in patients with treatment-resistant depression. Now, let’s explore why lower doses may actually be more effective. Understanding How Ketamine Works After 3 years of observing my patients’ amazing responses to treatment with low dose sublingual ketamine (LDSK), I wanted to understand more about how this medicine works. The standard explanation is that ketamine blocks NMDA receptors. These receptors bind glutamate, which is a chemical messenger found throughout the brain and body. By blocking NMDA receptors, ketamine increase “brain-derived neurotrophic factor” (BDNF), a protein…

“We are not thinking machines that feel; rather, we are feeling machines that think.” — Neuroscientist Antonio Damasio For over a century, workplace leadership has rested on a deeply ingrained belief that human beings are fundamentally rational. That assumption can be traced back to René Descartes, who over 300 years ago declared, “I think, therefore I am,” and made reason the defining feature of human behavior while marginalizing feelings and emotions. From this worldview emerged the conclusion that the most effective leaders should rely on intellect alone and suppress their own emotions. In turn, organizations prioritized analytical brilliance and sought…

Negative reinforcement is a frequently misused term that diminishes its value as a powerful tool for behavior change. You may be puzzled by the claim that negative reinforcement is actually a good thing. What’s so good about relying on discomfort, pressure, or nagging to motivate change? Why not rely on positive reinforcement instead? Research supports its effectiveness across many different domains and contexts. Praise, rewards, and support seem to be much more effective than criticism, penalties, and cruelty masked as tough love. Here is where the misunderstanding begins. While we are clear about what positive reinforcement means and how to…

It’s time to dust off those ball bags! MLB spring training has commenced. Pitchers and catchers are starting to report to Arizona and Florida for all 30 teams with Opening Day on March 25. Rosters are getting finalized and every team’s new offseason additions are getting their reps in — not to mention the much anticipated World Baseball Classic that will see the world’s best players compete on the international stage. Here are all the notable news and last-minute dealings as teams ramp up to Opening Day:Feb. 16Twins RHP Pablo Lopez ends bullpen session early Lopex ended a bullpen session early Monday over what…

What began as an unexpected observation and “side effect” of some medications converged with decades of addiction neuroscience: GLP-1 receptor agonist medications like Ozempic apparently reduce alcohol craving, drinking intensity, and relapses. If you or someone close to you struggles with alcohol use, it may help to know that medication originally developed for diabetes and obesity—semaglutide or other glucagon-like peptide-1 (GLP-1) receptor agonists—may one day become a treatment for alcohol use disorder (AUD). Not only may there be a new pharmacotherapy for AUD, but the success of these drugs forces a reconceptualization of addiction itself. This means AUD is not…

More than 100 years after its initial publication, the legendary Weird Tales Magazine is coming to life like never before in a new graphic novel that features adaptations of classic stories from the magazine’s hallowed history as well as original stories that expand the magazine’s enduring legacy. To celebrate the launch of a new Kickstarter campaign for the graphic novel as a collaboration by Monstrous and Weird Tales Magazine, we caught up with several of the talented writers behind the stories in the new graphic novel, including Rodney Barnes, Steve Niles, Blake Northcott, and Monstrous Press Editor and Publisher James…

The Patient Health Questionnaire-9 (PHQ-9) is a tool most clinicians are familiar with. It’s quick, familiar, and widely trusted across health care settings. However, when a patient’s results indicate high risk, they deserve more than a quick glance. It signals that they may be carrying a level of distress that affects mood, safety, functioning, and quality of life. How you respond in that moment matters. It can shape trust, determine next steps, and, in some cases, prevent serious harm. What Is the PHQ-9? The PHQ-9 is a nine-item screening tool used to assess the presence and severity of depressive symptoms.…

Let’s talk about something deeply weird that nobody wants to acknowledge: at some point in the late ’80s and early ’90s, America collectively decided it was totally fine to put a child murderer on lunchboxes, action figures, and breakfast cereal. Freddy Krueger, the razor-fingered monster who explicitly murdered children in their dreams, became a beloved mascot. Kids wore his face on t-shirts. Parents bought Freddy dolls for Christmas. MTV gave him a talk show. He became less “horrifying embodiment of parental failure and childhood trauma” and more “that funny burned guy with the one-liners.” And it all happened because of…

In a time when corruption no longer hides its face and political violence is increasing, outrage has become the default language of public life. Equanimity may seem irrelevant—or worse, complicit. What kind of person stays calm in the face of injustice? Who, in their right mind, resists the pull toward righteous indignation when world leaders violate essential norms of human decency? And yet, I’d like to suggest something quietly radical: that equanimity, rightly understood, is not passivity—but resistance. A deeper kind of resistance. One that refuses to be hijacked by the very forces it seeks to oppose. A few months…